Nemesis was created by the European Branch of the Umbrella Corporation's pharmaceutical company. He was designed to have immense strength and power, yet to also be intelligent enough to follow orders and overcome obstacles, but not intelligent enough to rebel. This particular Nemesis was deployed to Raccoon City to kill any remaining members of the S.T.A.R.S. unit, which had become an annoyance for the corporation. His first victim was Brad Vickers, who he impaled through the mouth with a tentacle.
Nemesis targeted Jill Valentine as his next victim. Jill managed to evade Nemesis throughout the city, but Nemesis continued to come after her, effortlessly taking down any obstacles in his way. After he shot down a rescue chopper and infected Jill with the T-Virus, Jill was forced to confront her attacker, managing to beat him with a barrage of explosives.